Phenytoin - Wikipedia
The correlation of cation transport with membrane-oriented sodium-potassium- adenosine triphosphatase (Na-K-ATPase) prompted an. Dilantin, also known as phenytoin, is a medication used in treating people with seizure disorders, also called epilepsy. According to the People's Pharmacy. Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti- seizure . In contrast to the earlier accidental discovery of the antiseizure properties of potassium bromide and phenobarbital, phenytoin was the does not mean that FDA has identified a causal relationship between the drug and the listed risk.
Vitamin D deficiencyas well as low calcium and phosphate in the blood cause decreased bone mineral density. Antacids administered in a peptic ulcer regimen may decrease the AUC of a single dose of phenytoin. Patients should be cautioned against concomitant use of antacids and phenytoin. Consider using other options if possible.
This is accomplished by reducing the amplitude of sodium-dependent action potentials through enhancing steady state inactivation. Sodium channels exist in three main conformations: Phenytoin binds preferentially to the inactive form of the sodium channel. Because it takes time for the bound drug to dissociate from the inactive channel, there is a time dependent block of the channel. Since the fraction of inactive channels is increased by membrane depolarization as well as by repetitive firing, the binding to the inactive state by phenytoin sodium can produce voltage-dependent, use-dependent and time-dependent block of sodium-dependent action potentials.
This includes the reduction of post-tetanic potentiation at synapses which prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of generalized tonic-clonic seizures. A small increase in dose may lead to a large increase in drug concentration as elimination becomes saturated.
Phenytoin and phenobarbital inhibit human HERG potassium channels.
The time to reach steady state is often longer than 2 weeks. Inoutside scientists including H. The extended release capsule should not be opened, as the entire dose would be delivered, so make sure to swallow it whole.
If you have been taking the immediate release version, you will probably have to get blood levels tested when you change to extended release, to make sure you have the right amount in the body.
It is made for specific types of seizures, so if you are thinking of trying it, you should consult with your doctor to find out if you are suffering from a type of seizure it can cause. Extended release versions are more convenient, as they only have to be taken once a day, and they can reduce or eliminate unwanted side effects. Side effects from this medication may include mild skin rash, itching, dizziness, nervousness, sleep problems, nausea, vomiting, constipation, headache, or joint pain.
Dilantin (Phenytoin) - Side Effects, Dosage, Interactions - Drugs
The following side effects are rare, but you should contact your doctor if you experience an allergic reaction, change in mood or behavior, depression, anxiety, agitation, hostility, restlessness, hyperactivity-mentally or physically, thought of suicide or hurting yourself, swollen glands, gums, easy bruising or bleeding, fever, sore throat, headache with blistering, confusion, hallucinations, slurred speech, loss of coordination.
Make sure to tell your doctor every medication you are taking, as Dilantin phenytoin can interact with many. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.
Patti Brown, PharmD Q: What are the possible long-term effects of phenytoin? I take phenytoin due to seizures which started after having a stroke 4 years ago. Phenytoin Dilantin is an anti-epileptic medication that works by slowing down the impulses in the brain that cause seizures.
Phenytoin is used to control certain types of seizures. Some of the possible side effects associated with treatment with phenytoin include mild skin rash or itching, dizziness, nervousness, insomnia difficulty sleepingheadache, joint pain, nausea, vomiting or constipation. According to the prescribing information available for Dilantin, the brand-name of phenytoin, Dilantin can cause rare, but serious, side effects including exfoliative dermatitis, Stevens-Johnson Syndrome SJS and toxic epidermal necrolysis TENwhich can be life-threatening and fatal.
It is important to be aware of the signs and symptoms of serious skin reactions so you can recognize them if they occur. Signs and symptoms include rash, blisters, fever or itching.How to Remember Drugs Causing Hyperkalemia in 6 Minutes
Contact your health care provider immediately if you experience any of these symptoms. Hyperglycemia elevated blood sugar has been reported with phenytoin treatment.
- Phenytoin and phenobarbital inhibit human HERG potassium channels.
- Anticonvulsant phenytoin affects voltage-gated potassium currents in cerebellar granule cells.
- There was a problem providing the content you requested
Another precaution with phenytoin treatment is the risk for osteomalacia softening of the bonesthought to be caused by phenytoin's interference with vitamin D metabolism. To ensure phenytoin is working optimally to control seizures, your doctor may perform routine blood work.
Foods Not to Eat While Taking Dilantin
It is essential to take phenytoin exactly as directed by your doctor. Do not take any other medications, prescription or over-the-counter, or drink alcohol, without first consulting with your doctor. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition.
This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis.